WebApr 29, 2024 · A punishment model, in which foot-shock is delivered to induce voluntary abstinence from cocaine has been used in at least two studies to date. Following a drug-free period, relapse to drug-seeking is induced by the drug itself (non-contingent cocaine), drug-paired cues, the drug-paired context, or cues+context. WebNov 22, 2002 · During the final stage of the extinction phase, a stimulus was conditioned to foot-shock stress (STRESS CS) by pairing a continuous white noise (70 dB) with foot …
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Web2 days ago · The mother of the shooter who killed five people at Old National Bank in Louisville, Kentucky, on Monday called 911 after hearing secondhand that her son had a gun and was heading toward the bank ... WebSep 1, 2000 · We have developed a reinstatement procedure that allows us to study the effect of stress on relapse to drug seeking in rats. Using this procedure, we have shown that exposure to intermittent... initiate platelegs osrs
(PDF) A Procedure for Studying the Footshock-Induced Reinstatement …
WebMay 2, 2011 · The most commonly used animal model of relapse following drug self-administration is the extinction-reinstatement paradigm. Once stable self-administration is established and maintained, animals undergo extinction of responding, whereby access to the drug is discontinued. WebJun 10, 2024 · Active/inhibitory avoidance required flexible discrimination between auditory cues signaling foot-shock could be avoided by making or withholding instrumental responses. On a simpler active avoidance task, a single cue signaled when a lever press would avoid shock. WebMar 27, 2024 · Then mice underwent an FR2 self-administration schedule of reinforcement for 50 min with two scheduled changes: after one active response, mice received an electric foot-shock (0.18 mA, 2 s), while after the second response, the electric foot-shock was paired with the drug delivery and the associated cue light. initiate personality interface or wipe system