NettetFerroptosis is defined as an iron-dependent, non-apoptotic form of programmed cell death characterized by the accumulation of intracellular soluble and lipid reactive … Nettet1. des. 2024 · Ferroptosis is unique among the different cell death modalities, as it has been mostly linked to pathophysiological conditions and because several metabolic ... A recent study further proposed that GPX4 mRNA expression is positively regulated by α6β4 integrin (Brown et al., 2024), albeit the underlying mechanism remains to be ...
Integrin αvβ3 Is a Master Regulator of Resistance to TKI-Induced ...
Nettet8. apr. 2024 · The integrins help in bidirectional communication and activate profibrotic cytokine, predominantly TGF-β1 to help in the establishment of highly cross-linked ECM. ... A study conducted by Chung et al., formulated iron-based NPs loaded with sorafenib to facilitate the ferroptosis of the tumor. NettetThe integrin α6β4 activates Src to inhibit ferroptosis. (A) Vector control and β4-depleted cells were assessed for phosphorylated (Y418) Src by immunoblotting 3 h after ECM detachment. Relative... supercharger for 2009 mustang gt
Bioinformatics analysis of potential key ferroptosis-related genes ...
NettetTo date, little is known about the mechanisms that protect ECM-detached tumor cells from ferroptosis and thus survive. Brown et al. reported that a6b4 integrin promotes … Nettet14. feb. 2024 · Collectively, these results indicate that pharmacological inhibition of αvβ3 integrin mimics the effect of β3 integrin receptor KO on reversing resistance to neratinib-induced ferroptosis as well as cross-resistance to other ferroptosis inducers (Erastin and RSL3), and partially restores the sensitivity of neratinib-resistant cells to other non … Nettet20. jan. 2024 · SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway Our study suggests that SLC3A2 negatively regulates ferroptosis through mTOR pathway in laryngeal carcinoma. Our study suggests that SLC3A2 negatively regulates ferroptosis through mTOR pathway in laryngeal carcinoma. supercharger for 350 vortec