WebMyocarditis is an inflammatory heart disease that can be initiated by infectious pathogens.1–3Dilated cardiomyopathy, which may follow myocarditis and represent the chronic stage of disease, is a major cause of heart failure and heart transplantation.4–6Evidence suggests that autoimmune responses to cardiac antigens … WebOct 30, 2024 · In addition to the rare and often fulminant cardiotoxicity of myocarditis, emerging data suggest that pericardium and cardiac vasculature are also targeted. 3 However, myocarditis has the highest mortality (up to 50%), which underscores the importance of its diagnosis and treatment.3 Myocarditis is estimated to occur in 1.1% of …
Myocarditis - Diagnosis and treatment - Mayo Clinic
WebMar 1, 2004 · Myocarditic epitope is located in the S2 fragment of cardiac myosin The myocarditis inducing capacity of S2–16 was Lewis strain-specific Enhanced cellular immune responses against S2–16 correlate with disease in immunized Lewis rats S2–16 is a cryptic epitope with characterization of Ab and lymphocyte responses in S2–16 and HCM … WebJun 1, 2007 · The induction of myhcα peptide-specific Th cells in the course of both infections suggests that infection-associated determinant spreading on the Th cell level paves the way for a focused and dominant anti-myhcα B cell response. ... (Ac-RSLKLMATLFSTYASADR-OH) was used for induction of autoimmune myocarditis. … davyfields eccleshill
Molecular mapping of autoimmune B cell responses in …
WebSep 16, 2024 · Myocarditis is an infrequent but highly hazardous complication of the cancer therapy of immune checkpoint inhibitors (ICIs). The study of the pathophysiology of this disease is an active field of research and a clearer comprehension of the mechanisms is crucial to provide an accurate diagnosis, appropriate therapy, and to prevent cardiac … WebDec 1, 2016 · One such model for cardiac autoimmunity is experimental autoimmune myocarditis (EAM), which involves induction of disease in susceptible rodent strains by immunizing animals with cardiac antigens or their peptide fragments.23, 24, 25In this study, we used the EAM model in A/J mice to demonstrate that ANT1possesses multiple … WebNov 16, 2003 · Dendritic cells induce myocarditis. Induction of autoimmunity requires the administration of autoantigens, together with strong adjuvants such as complete Freund … davy field ingoldisthorpe